We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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SARRP Research Spotlight: Dr. George Wilson
George Wilson, PhD, Chief, Radiation Biology, William Beaumont Hospital Radiation Biology focuses on translational research in the areas of new treatments, combined modalities, and stem cell biology. The group has a heavy emphasis on incorporating molecular,...
