Small animal radiotherapy research platforms such as Xstrahl's SARRP enable more precise irradiation of tumours and normal tissues in pre-clinical models of cancer. In their study “Evaluation of four different small animal radiation plans on tumour and normal...
In their paper “Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation” Bell BI, Koduri S, Salas Salinas C, et al, aim to evaluate the acute changes in leukocyte populations after focal irradiation and to assess the role...
Radiotherapy is recognized as one of the main modalities for the treatment of cancer in the world, the translation of the results of the pre-clinical research to clinical trials represents an optimization of the resources destined to combat this disease. Improvements...
Meningiomas are a frequent tumor of the central nervous system. Although mostly benign, approximately 5% present as atypical or malignant tumors. Treatments for atypical meningiomas include gross total resection and radiotherapy, but about 33% of patients have...
An 'abscopal' effect if often used to refer to distant tumour regression after localised irradiation. Since the first report of the abscopal effect in the 1950s, well-documented cases with radiotherapy alone are very rare. It is widely accepted that the immune...
Craniospinal irradiation (CSI) is a crucial component of treatment for medulloblastoma (MB), a brain tumor clinically stratified into prognostically distinct molecular subgroups. Preclinical models of clinically relevant CSI offer the potential to study radiation dose...
Tumor hypoxia reduces the effectiveness of radiation therapy by limiting the biologically effective dose. An acute increase in tumor oxygenation before radiation treatment should therefore significantly improve the tumor cell kill after radiation. Efforts to increase...
Inhibition of ataxia-telangiectasia mutated (ATM) during radiotherapy of glioblastoma multiforme (GBM) may improve tumor control by short-circuiting the response to radiation-induced DNA damage. A major impediment for clinical treatment is that current inhibitors have...
The face of skin cancer is changing, as awareness is at an all-time high and medical technology is rapidly advancing. Still, the Skin Cancer Foundation reports that more than 5.4 million cases of nonmelanoma skin cancer are treated each year in the U.S., affecting 3.3...